Sugar consumption and its role in dental caries: Insights from a 2-sample Mendelian randomization study.

ABSTRACT: Dental caries is a prevalent chronic disease influenced by both genetic and environmental factors, particularly dietary. Using a 2-sample Mendelian randomization (MR) approach with genome-wide association study data, this study examined the potential causal relationship between sugar preference, diabetes, and dental caries. The research seeks to clarify the influence of genetic predispositions and metabolic conditions, such as diabetes, on dental health. We conducted a 2-sample MR analysis using genome-wide significant single nucleotide polymorphisms (P < 5 × 10⁻⁸), linkage disequilibrium pruning (R2 < 0.001), and multiple MR methods including inverse-variance weighted, MR-Egger, robust adjusted profile score, and MR-PRESSO. Genetic variants associated with exposures were harmonized with o

SUBMITTER: Lim SW 

PROVIDER: S-EPMC12727404 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature