Genetically predicted modifiable risk factors for Helicobacter pylori infection: A Mendelian randomization study.

ABSTRACT: This Mendelian randomization (MR) study aimed to investigate causal relationships between modifiable factors and Helicobacter pylori (H pylori) infection risk. These factors included lifestyle, socioeconomic, and nutritional variables. Bidirectional 2-sample MR analyses were conducted using genetic instruments derived from genome-wide association studies in Europeans. Primary analyses employed inverse variance weighting, supported by MR-Egger, weighted median, and pleiotropy-robust methods. Sensitivity analyses included Cochran Q test, MR-Egger intercept, and leave-one-out validation. Potential reverse causation was evaluated by reverse MR. Genetically predicted smoking initiation (odds ratio [OR]: 1.079, 95% confidence interval [CI]: 1.013-1.148, P = .017), prolonged television viewing (O

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12727420 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature