Plasma aldosterone is low in patients hospitalized with COVID-19 and not associated with changes in serum potassium levels: <i>post hoc</i> observational analyses of clinical trial data.

ABSTRACT:

Background

Hypokalemia is common in patients hospitalized with coronavirus disease 2019 (COVID-19) and is associated with mortality, disease progression and severity. Increased aldosterone levels were previously suggested to be the main cause of potassium loss in this population. We aimed to assess the effects of the latest morning plasma aldosterone levels on changes in serum potassium during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Methods

We used dynamic generalized estimating equations (GEEs) on longitudinal data (3 weeks) from an adequately sized (159 patients) platform trial evaluating therapeutics for COVID-19 during the first wave of infections in Vienna, Austria. We adjusted for important confounding variables (GEE A, 106 patients) and

SUBMITTER: Krenn S 

PROVIDER: S-EPMC12727438 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature