Radiofrequency Ablation and Cryoablation in Treating Painful Bone Metastasis: A Comprehensive Systematic Review and Separate Single-Arm Meta-analysis.

ABSTRACT:

Background and aim

Bone metastases cause pain and disability in advanced prostate, breast, and lung cancers. Traditional treatments may not work for all patients. Minimally invasive procedures such as cryoablation (CA) and radiofrequency ablation (RFA) have emerged as good options. This review aims to evaluate and summarize the effectiveness and safety of CA and RFA separately in managing painful bone metastases.

Methods

We performed a comprehensive search of Ovid Medline, Google Scholar, Web of Science, CENTRAL, and ClinicalTrials.gov covering studies published between January 2000 and January 2025. The search included English-language cohorts. or randomized trials of adults (≥18 years) with bone metastases treated using RFA or CA. Outcomes such as pain levels, tumor recurr

SUBMITTER: Alaqeel M 

PROVIDER: S-EPMC12727478 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature