A subnanolitre tetherless optoelectronic microsystem for chronic neural recording in awake mice.

ABSTRACT: The long-term recording of neural activity could be used to understand complex behaviours and disorders. However, the development of technology capable of such measurements faces a variety of technical challenges, including the relative motion between recording electrodes and tissue and the excessive displaced volume from implanted electronics. Here we report a subnanolitre-volume tetherless optoelectronic microsystem for neural recording. The system relies on light for photovoltaic power and data transfer, through a light-emitting diode, eliminating the need for wires or other tethers. It uses a single AlGaAs diode as both photovoltaic and light-emitting diode. Complementary metal-oxide-semiconductor circuits provide low-noise amplification, pulse-position-modulated encoding and electro-o

SUBMITTER: Lee S 

PROVIDER: S-EPMC12727521 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature