Secretome translation shaped by lysosomes and lunapark-marked ER junctions.

ABSTRACT: The endoplasmic reticulum (ER) is a highly interconnected membrane network that serves as a central site for protein synthesis and maturation¹. A crucial subset of ER-associated transcripts, termed secretome mRNAs, encode secretory, lumenal and integral membrane proteins, representing nearly one-third of human protein-coding genes¹. Unlike cytosolic mRNAs, secretome mRNAs undergo co-translational translocation, and thus require precise coordination between translation and protein insertion^2,3. Disruption of this process, such as through altered elongation rates⁴, activates stress response pathways that impede cellular growth, raising the question of whether secretome translation is spatially organized to ensure fidelity. Here, using live-cell sin

SUBMITTER: Choi H 

PROVIDER: S-EPMC12727531 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature