The predictive value of the FT3/FT4 ratio for the severity of coronary artery disease in patients with acute coronary syndrome.

ABSTRACT:

Background and aims

Thyroid hormones critically regulate cardiovascular homeostasis, with thyroid dysfunction established as an independent risk factor for coronary artery disease. While free triiodothyronine (FT3) to free thyroxine (FT4) ratio reflects peripheral thyroid hormone conversion efficiency, its prognostic utility for anatomical severity of coronary lesions in acute coronary syndrome (ACS) remains undetermined.

Methods and results

This observational study enrolled a total of 431 ACS patients who underwent coronary angiography. The anatomical severity of coronary lesions was quantified by SYNTAX score. Patients were stratified into three groups based on tertiles of the FT3/FT4 ratio: T1 (FT3/FT4 ≤0.27, n = 144), T2 (0.27 < FT3/FT4 ≤0.33, n = 144), and T3 (FT3/FT4 >

SUBMITTER: He H 

PROVIDER: S-EPMC12727579 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature