Changes in maintenance immunosuppression after pediatric kidney transplantation-a report from the Nordic pediatric kidney transplantation registry.

ABSTRACT:

Background

Few studies are available on changes in maintenance immunosuppression after pediatric kidney transplantation (KT). This is a retrospective registry analysis of the long-term medication modifications in the Nordic countries.

Methods

All pediatric KT recipients transplanted between the years 2005 and 2016 were identified from the Scandiatransplant registry. Of the 482 patients, 345 met the inclusion criteria: age below 16 years at KT and at least 2 years post-transplant follow-up.

Results

A change in maintenance immunosuppression occurred in 160 patients (46.4%) at 2.0 (interquartile range 1.0-3.0) years median time from KT. The most common change (35.8%) was switching cyclosporine A (CsA) to tacrolimus (Tac). Initial CsA treatment was modified significantly

SUBMITTER: Kaijansinkko H 

PROVIDER: S-EPMC12727704 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature