Analysis of antibiotic resistance and cagPAI variability in Helicobacter pylori strains from Malaysian patients.

ABSTRACT: Antibiotic resistance and virulence factor of Helicobacter pylori pose formidable challenge towards eradication of this pathogen. Heterogeneity of H. pylori cagPAI is essential in the emergence of antibiotic resistance. The objective of this study was to investigate the correlation between antibiotic resistance and cagPAI variability among H. pylori strains in multiethnic Malaysian patients. H. pylori antibiotic susceptibility profile to six antibiotic classes was determined using E-test and the presence of each cagPAI gene was determined using polymerase chain reaction (PCR). The highest resistance was observed against metronidazole (58.6%, 34/58), followed by clarithromycin (36.2%, 21/58), and levofloxacin (25.9%, 15/58); all strains were susceptible to amoxicillin, tetracycline and rifa

SUBMITTER: Razak SA 

PROVIDER: S-EPMC12727713 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature