Slight acceleration in podocyte mRNA loss in preterm-born children aged 3-5 years.

ABSTRACT:

Background

The global survival rate of preterm infants has been progressively increasing. However, concerns regarding their long-term prognosis persist. This study aimed to investigate podocyte mRNA loss in 3-5-year-old full-term and preterm children to elucidate the role of podocyte depletion in the pathogenesis of chronic kidney disease (CKD) in preterm infants.

Methods

A total of 80 children aged 3-5 years, born at Tianjin Central Hospital of Gynecology and Obstetrics, were included in this study: 42 preterm infants (gestational age 24-29 weeks) and 38 full-term infants. Morning urine samples were collected to examine podocyte mRNA levels (expressed as the urinary podocin mRNA-to-creatinine ratio, UpodCR), urine protein, and urine albumin levels. The impact of perinatal f

SUBMITTER: Cui Z 

PROVIDER: S-EPMC12727743 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature