Comparison of efficacy, safety, immune response of dNS1 LAIV and cold-adapted LAIV in a mouse model.

ABSTRACT: Influenza remains a significant global public health concern. Live-attenuated influenza vaccines (LAIVs) are recognized as effective interventions for influenza prevention. Currently, two types of LAIVs are licensed for human use: one developed through cold-adapted viral gene mutation and the other through the deletion of the viral NS1 gene. However, the similarities and differences in these two LAIVs' efficacy, safety, and immune responses have not been thoroughly studied. This study constructed a gene-deficient live-attenuated vaccine strain, CA4-dNS1, and a gene locus-mutated attenuated vaccine strain, CA4-cold, to compare their in vivo and in vitro replication capacity, broad-spectrum protective efficacy, safety, and immunogenicity. The results showed that both LAIVs provide comparable

SUBMITTER: Wang X 

PROVIDER: S-EPMC12727762 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature