LINC01116 promotes nascent protein synthesis and cellular stemness through the miR-432-5p/FKBP7/14 regulatory axis in melanoma.

ABSTRACT: Skin cutaneous melanoma (SKCM) is a highly aggressive and malignant neoplasm. A wealth of evidence highlights the critical role of LINC01116 in tumorigenesis and progression. Additionally, numerous small molecules within the FK506-binding protein (FKBP) family have been implicated in cancer development. Herein, we interrogated the functional significance of lncRNA LINC01116 and FKBP7/14 in melanoma pathogenesis. This study aim to the expression of long non-coding RNA (lncRNA) LINC01116 in melanoma and its mechanistic role in promoting de novo protein synthesis and cancer stemness through the miR-432-5p/FKBP7/14 axis. A competing endogenous RNA (ceRNA) network for LINC01116 was constructed through bioinformatics analysis. LINC01116 expression levels were assessed in clinical melanoma tissue

SUBMITTER: Sun Y 

PROVIDER: S-EPMC12727800 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature