Deep learning-based detection of murine congenital heart defects from µCT scans.

ABSTRACT: Micro-computed tomography (μCT) provides 3D images of congenital heart defects (CHD) in mice. However, diagnosing CHD from μCT scans is time-consuming and requires clinical expertise. Here, we present a deep learning approach to automatically segment and screen normal from malformed hearts. On a cohort of 139 μCT scans of control and mutant mice, our diagnosis model achieves an area-under-the-curve (AUC) of 97%. For further validation, we acquired two additional cohorts after model training. Performance on a similar 'prospective' cohort is excellent (AUC: 100%). Performance on a 'divergent' cohort containing novel genotypes is moderate (AUC: 81%), but improves markedly after model finetuning (AUC: 91%), showcasing robustness and adaptability to technical and biological differences in the d

SUBMITTER: Nguyen H 

PROVIDER: S-EPMC12727836 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature