Macrophage migration inhibitory factor and angiopoietin-like protein 4 as markers for steroid response in children with idiopathic nephrotic syndrome.

ABSTRACT:

Background

Idiopathic nephrotic syndrome (INS) is a significant kidney disorder in pediatrics. Early diagnosis of minimal change disease (MCD) is difficult in children with nephrotic syndrome (NS). Angiopoietin-like protein 4 (ANGPTL4), found on the surface of podocytes, has been linked to nephrotic syndrome (NS) and plays a role in triggering proteinuria. Macrophage migration inhibitory factor (MIF) functions as a crucial modulator of the innate immune system and partly counteracts glucocorticoid-induced immune system inhibition. This study aimed to assess the role of ANGPTL4 and MIF as biomarkers in steroid responsiveness of INS.

Methods

This cross-sectional comparative study involved 70 children with NS and 40 healthy children as a control group.

Results

Urinary MI

SUBMITTER: Al Dash H 

PROVIDER: S-EPMC12727841 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature