Peroxisomes in the mouse ovary and their alterations during follicular development and oocyte maturation.

ABSTRACT: Peroxisomes are the site of important metabolic pathways as they contain enzymes involved in the β-oxidation of fatty acids, the degradation of reactive oxygen species and the synthesis of ether-lipids and steroid hormone precursors. They are present in virtually all eukaryotic cells, yet they demonstrate considerable heterogeneity of number and protein composition. The presence of peroxisomes and concomitant activity of peroxisomal enzymes was previously documented in ovarian cells and it was suggested that peroxisomal oxidative stress management through catalase plays a pivotal role during oogenesis. In the present article, an exhaustive analysis is presented of the changes in peroxisome abundance during folliculogenesis in mouse oocytes. To this end, a quantitative assessment of the num

SUBMITTER: Colasante C 

PROVIDER: S-EPMC12727866 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature