Neuroprotective effects of hyperbaric oxygen therapy on vascular cognitive impairment in hypoperfused mice via miR-137-3p/TRAF3 pathway.

ABSTRACT: Vascular cognitive impairment (VCI), a prevalent form of dementia resulting from chronic cerebral hypoperfusion (CCH), remains devoid of effective therapeutic strategies. While hyperbaric oxygen therapy (HBOT) has shown promise in mitigating neurological damage, its molecular mechanisms remain incompletely elucidated. Here, we demonstrate that HBOT confers robust neuroprotection against CCH-induced VCI through the microRNA-137-3p (miR-137-3p)/TNF receptor-associated factor 3 (TRAF3) signaling axis. In a mouse model of CCH, prolonged HBOT administration significantly improved cognitive performance across multiple behavioral domains-including spatial, recognition, and contextual memory-concomitant with enhanced cerebral blood flow and oxygen saturation. Mechanistically, HBOT upregulated hipp

SUBMITTER: Yang L 

PROVIDER: S-EPMC12727875 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature