Maternal and neonatal outcomes in obstetric antiphospholipid syndrome: a retrospective case-control study.

ABSTRACT:

Objective

The combination of low-dose aspirin (LDA) and low-molecular-weight heparin (LMWH) is the standard of care for obstetric antiphospholipid syndrome (OAPS), significantly improving live birth rates. However, whether this regimen fully normalizes the pregnancy course and mitigates risks for both the mother and the neonate remains unclear. This study aimed to systematically evaluate whether significant maternal and neonatal morbidity persists in OAPS patients despite successful treatment and live birth.

Methods

This retrospective cohort study included 256 OAPS patients, including 166 criteria OAPS patients (C-OAPS-patients who fulfilled both the clinical and laboratory criteria of the Sydney criteria) and 90 non-criteria OAPS patients (NC-OAPS-patients who fulfilled onl

SUBMITTER: Rao L 

PROVIDER: S-EPMC12727887 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature