Inflammation mediation of the association between brominated flame retardants and psoriasis among U.S. adults.

ABSTRACT:

Background

Brominated flame retardants (BFRs), widely applied in fire prevention, are persistent environmental pollutants. Accumulating evidence indicates that BFRs can trigger inflammatory responses in humans, potentially contributing to various diseases. Given the central role of inflammation in psoriasis pathogenesis, investigating the association between BFR exposure and psoriasis risk is of considerable importance.

Methods

We analyzed data from the 2005-2006 and 2009-2014 cycles of the National Health and Nutrition Examination Survey (NHANES). concentrations of BFRs were natural logarithmic transformed and categorized into quartiles. The association between BFR exposure and psoriasis was evaluated using multivariable regression models, restricted cubic spline analysis,

SUBMITTER: Jiang M 

PROVIDER: S-EPMC12727945 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature