PRR enhances anti-tumor immunity and suppresses colitis by promoting the development and survival of naive T and iNKT cells.

ABSTRACT: The (pro)renin receptor (PRR) is a multifunctional transmembrane protein that enhances β-catenin/TCF1 signaling and V-ATPase-mediated lysosomal acidification. Emerging evidence indicates that it may also regulate potential roles in regulating T cell development, survival, and immune responses. Here, we demonstrated that PRR promotes the maturation and survival of T cells within the thymus. In particular, PRR-deficient mice exhibited a significant reduction in iNKT cells in the thymus and periphery. PRR promoted the energy synthesis process in mitochondria, as evidenced by increased mitochondrial amount and membrane potential. This phenomenon was accompanied by an increase in TCF1 expression and lysosomal acidification. Furthermore, PRR enhanced the survival of naive T and iNKT cells in the

SUBMITTER: Shimba A 

PROVIDER: S-EPMC12727963 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature