Identification and validation of tumor microenvironment-related therapeutic targets in gastric cancer using integrated multi-omics and molecular docking approaches.

ABSTRACT:

Introduction

With increased drug resistance and tumor heterogeneity accounting for limited therapeutic strategies, gastric cancer remains one of the major causes of cancer-related mortality around the globe. Targeting the components of the tumor microenvironment (TME) has become a promising therapeutic strategy due to their crucial roles in cancer cell proliferation, progression, and metastasis. One of the limitations of the previously identified therapeutic targets is their limited applicability to a broader patient population.

Methods

This study aims to identify (TME)-related therapeutic targets using an integrated bioinformatics and molecular docking approach that involves a larger number of datasets to cover a broader cohort of gastric cancer patients. It analyzed multip

SUBMITTER: Oli M MK 

PROVIDER: S-EPMC12727970 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature