Neurogenic locus notch homolog protein 1 (NOTCH 1) SNP informatics coupled with intrinsically disordered regions and post-translational modifications reveals the complex structural crosstalk of Lung Adenocarcinoma (LUAD).

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is the predominant histological subtype of lung cancer, representing a major contributor to cancer mortality rate marked by a high frequency of mutations and intricate interactions between multiple signalling pathways.

Objective

Here we explore the role of NOTCH1 associated Single nucleotide polymorphisms (SNPs) IDR and PTM in LUAD progression. Although the NOTCH1 expression is downregulated, it has been validated as an important prognostic marker because of its complex biological roles under specific conditions.

Methods

With the aid of In silico tools we predicted and identified the deleterious SNPs. The Molecular Docking and dynamics simulations (MDS) were conducted to characterize these mutations.

Results

A total of 43 d

SUBMITTER: John P 

PROVIDER: S-EPMC12727990 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature