Characteristic of cerebral hemodynamics and functional connectivity in patients with neuropathic pain after spinal cord injury: an exploratory study.

ABSTRACT:

Background

This study investigated the brain functional characteristics of patients with neuropathic pain (NP) following spinal cord injury (SCI) using functional near-infrared spectroscopy (fNIRS).

Methods

A total of 35 subjects were enrolled, including 10 able-bodied controls, 12 patients with SCI and NP (SCI-NP), and 13 patients with SCI (without NP). fNIRS was used to detected blood oxygen signals during motor tasks and resting-state (RS) functional connectivity (FC) in the subjects. We also performed Pearson correlation analyses of pain scores (NPS) and the Pittsburgh Sleep Quality Index (PSQI) in patients with SCI-NP. Statistical analyses were performed using Shapiro-Wilk test for normality; paired t-test for intra-group differences; ANOVA (LSD post-hoc,

SUBMITTER: Yu Y 

PROVIDER: S-EPMC12728002 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature