A 41-marker 37-color full spectrum flow cytometry panel for the deep immunophenotyping of human peripheral and liver natural killer cells.

ABSTRACT: Natural killer cells (NK cells) are granular lymphocytes with cytotoxic activity that have a role in both innate and adaptive immune responses. NK cells consist of a diverse array of phenotypes with specific functions imposed by the microenvironment. Liver NK cells are an abundant lymphocyte population playing a key role in tuning immune responses under physiological and pathological conditions. For example, NK cell functional and phenotypic changes occur during liver cancer progression and correlate with disease prognosis. As liver cancer has the second-highest mortality rate among solid cancers, it is important to define the composition and the dynamics of the liver and peripheral NK cell compartment both in health and disease state. In-depth analysis of the phenotypes and functional sta

SUBMITTER: Paul AGA 

PROVIDER: S-EPMC12728072 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature