Extracellular vesicles-derived non-coding RNA in leukemias and pre-leukemic syndromes: a systematic review.

ABSTRACT:

Background

Hematological malignancies, including leukemia, lymphoma, and multiple myeloma, are among the most aggressive cancers, with high mortality rates and limited early diagnostic tools. Exosomes, nano-sized extracellular vesicles secreted by numerous cells including tumor cells, have emerged as promising biomarkers due to their stability, non-invasive isolation, and disease-specific molecular cargo, particularly non-coding RNAs (ncRNAs).

Method

This systematic review, conducted following PRISMA 2020 guidelines, evaluated the diagnostic and prognostic potential of exosomal ncRNAs in hematological malignancies by analyzing 16 studies from five databases (Scopus, PubMed, Embase, Web of Science, and ProQuest).

Result

Key findings revealed that exosomal microRNAs, su

SUBMITTER: Seddighi N 

PROVIDER: S-EPMC12728150 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature