Prostate cancer cells converge to an inflammatory-like state upon metastatic dissemination.

ABSTRACT: Identifying drivers of cancer progression to guide treatment selection is hindered by our limited understanding of tumor heterogeneity and its impact on tumor evolution. Here, we delineate the phenotypic variability across ~300,000 cells collected from multiple tumor loci in primary prostate and matched locoregional metastases using single-cell chromatin accessibility and gene expression sequencing. We find inter-patient heterogeneity to be confined to malignant populations. Within individual tumor loci, we see phenotypic heterogeneity among malignant cell populations despite a shared clonal genotypic architecture. We also observe that malignant cell populations disseminating to locoregional lymph nodes mirror the clonal architecture and phenotypic heterogeneity across primary tumor loci,

SUBMITTER: Keshavarzian T 

PROVIDER: S-EPMC12728229 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature