Mortality Among Patients With Invasive Group A Streptococcal Infections Caused by the M1UK Lineage: A Retrospective Cohort Study in England and Wales.

ABSTRACT:

Background

The M1UK sublineage of Streptococcus pyogenes has driven recent post-pandemic surges in invasive group A streptococcal (iGAS) disease. We assessed case fatality rate (CFR) among patients with emm1 iGAS in England and Wales, and then compared outcomes associated with M1UK and ancestral emm1 lineages.

Methods

We linked emm1 iGAS cases (December 2009-July 2022) with demographic and mortality records. Lineage was determined for isolates collected in 2010, 2013-2016, and 2020 via whole-genome sequencing or allele-specific PCR. Seven- and 30-day all-cause CFRs were estimated. Univariate and multivariate models assessed the association between lineage and risk of death.

Results

Among 4952 emm1 iGAS cases, lineage was assigned to 1356. The 30-day CFR was 24.4% for

SUBMITTER: Li HK 

PROVIDER: S-EPMC12728285 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature