Risk of Placenta Accreta Spectrum With Early Pregnancy Subchorionic Hematoma Location and Size in Hormone Replacement Cycles.

ABSTRACT:

Purpose

To study whether subchorionic hematoma (SCH) location and size in early pregnancy affect placenta accreta spectrum (PAS) risk in hormone replacement cycles (HRC).

Methods

Retrospective cohort study of 685 singleton live births following frozen-thawed embryo transfer in HRC (November 2018-September 2023) at a single fertility clinic. SCH location (cervical-side, mid-cavity, or fundal-side) and size (< 10% or > 50% of gestational sac), assessed by first-trimester ultrasound, were evaluated for association with PAS.

Results

The presence of SCH showed a trend toward increased PAS frequency (adjusted Risk Ratio (RR) 1.56, 95% Confidence Interval (CI) 0.87-2.80). Location-specific analysis revealed that cervical-side SCH conferred significantly elevated PAS risk com

SUBMITTER: So S 

PROVIDER: S-EPMC12728315 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature