Streptocyclin BTW is a novel member of a diverse family of circular bacteriocins in the genus Streptococcus.

ABSTRACT: Members of the genus Streptococcus are gram-positive bacteria, commonly found in humans and animals. This group of microorganisms has been associated with severe infections and the development of resistance to antibiotics and production of bacteriocins. Many class I bacteriocins, especially lanthipeptides, have been described for streptococci; however, only one circular bacteriocin has been described for the group (uberolysin). The objective of this study was to characterize streptocyclin BTW, a 64 amino acid circular bacteriocin produced by Streptococcus devriesei DSM 19639, as well as to assess the diversity of circular bacteriocins within the genus. Streptocyclin BTW displayed a broad inhibitory spectrum with pronounced activity against strains of streptococci. A colony mass spectrum of

SUBMITTER: Farias FM 

PROVIDER: S-EPMC12728389 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature