Recurrent ischaemic strokes as a first presentation of Libman-Sacks endocarditis with an atypically massive mitral vegetation resulting in severe valvular regurgitation: a case report.

ABSTRACT:

Background

Libman-Sacks endocarditis is a form of non-bacterial thrombotic endocarditis, associated with autoimmune conditions such as systemic lupus erythematosus and antiphospholipid syndrome (APLS). Vegetations are usually small and are managed with immunosuppression and anticoagulation.

Case summary

A 50-year-old female presented to her hospital with left leg weakness, with imaging showing a right parietal stroke and an old occipital lobe stroke. Inpatient transthoracic echocardiography showed a large mitral valve (MV) vegetation with moderate-to-severe mitral regurgitation (MR). She self-discharged against medical advice before further workup could be completed and was lost to follow-up until persuaded to have an outpatient transoesophageal echocardiogram, which showed

SUBMITTER: Tang PT 

PROVIDER: S-EPMC12728410 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature