Associations Between Left DLPFC iTBS-induced Functional Connectivity Changes and Depressive Symptoms: An Exploratory Study.

ABSTRACT:

Background

As a more efficient variant of repetitive transcranial magnetic stimulation (rTMS), intermittent theta-burst stimulation (iTBS) has been shown to effectively treat major depressive disorder (MDD). Resting-state functional connectivity (FC) is believed to help explain how iTBS exerts its therapeutic effects. Research findings regarding FC changes induced by iTBS targeting the left dorsolateral prefrontal cortex (DLPFC) are inconsistent, warranting exploratory investigations. In this study, we analyzed the effects of a 10-day iTBS treatment on changes in resting-state FC in patients with MDD.

Methods

This study enrolled 29 patients with MDD from Tianjin Anding Hospital between February 2023 and November 2024. These patients received 10 days of left DLPFC iTBS treatm

SUBMITTER: Kun Xie 

PROVIDER: S-EPMC12728542 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature