Chloroalkylation of Unactivated Alkenes via a Cobalt-Mediated Radical Ligand Transfer (RLT) Photoredox Catalysis Platform.

ABSTRACT: The development of modular difunctionalization strategies for unsaturated hydrocarbons is of particular interest, as it enables access to complex building blocks in a single step. Although great progress has been recently achieved in this field, difunctionalization of simple, nonconjugated alkenes represents a substantial challenge. Inspired by the radical rebound paradigm found in metalloenzymes, radical ligand transfer (RLT) catalysis has recently emerged as a powerful and broadly applicable strategy for the selective functionalization of alkyl radicals. Here, we present our advancements on the metallaphotoredox platform, which leverages the efficient cooperation between photoredox and cobalt RLT catalysis. A variety of electrophilic, functionalized carbon-centered radicals can be genera

SUBMITTER: Patra S 

PROVIDER: S-EPMC12728606 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature