Regioselective Glycosylation of Fluorine-18-Labeled Sorbitol for Enhanced Bacterial Detection In Vivo Using PET.

ABSTRACT: Precise and rapid detection of bacterial infection in vivo remains a significant challenge in clinical practice. In response to this challenge, several pathogen-specific positron emission tomography (PET) tracers have been developed, including the fluorine-18-labeled sorbitol derivative [¹⁸F]-FDS, which shows great promise in detecting bacterial infections in patients. In this study, we tested the hypothesis that the diagnostic performance of [¹⁸F]-FDS could be modulated via regioselective glycosylation to improve radiotracer stability, broaden organism sensitivity, and tune pharmacodynamics. A synthetic sequence was developed, whereby the common radiotracer [¹⁸F]-FDG was converted chemoenzymatically to α- and β-linked disaccharides via reverse phosphorolys

SUBMITTER: Lee SH 

PROVIDER: S-EPMC12728616 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature