Dockground: Expanding the Resource to Protein-DNA Complexes.

ABSTRACT: Proteins and nucleic acids function by interacting with each other and with other molecules. Protein interactions with DNA are the basis of key cellular processes, such as replication, transcription, packaging, and DNA repair. To understand the mechanisms of these processes, it is important to know the structure of the molecular components and their interactions. Structures of protein complexes with nucleic acids are especially difficult to solve experimentally due to their greater instability. Thus, relatively few experimentally determined structures of such complexes are available. Computational modeling is essential for understanding biomolecular mechanisms and for the development of our ability to modulate them. Advances in the protein structure prediction field have shown that protein

SUBMITTER: Collins KW 

PROVIDER: S-EPMC12728743 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature