Helix Regulation of Poly(phenylacetylene)s through the Interplay between Enantiomeric Excess and Temperature-Triggered Pendant Isomerization.

ABSTRACT: The isomerization of pendant groups plays a crucial role in modulating helical structures and biological activity in both biomacromolecule and dynamic helical conjugated polymers. While the effects of solvents, pH, and temperature on pendant isomerization and helix preference have been extensively studied, the combined influence of pendant isomerization and enantiomeric excess remains largely unexplored. Herein, we report a dynamic helical poly-(phenylacetylene) (PPA) system, poly-[D _r -co-L _(1-r)], in which the helix preference is dictated and nonlinearly amplified via the "majority rule" mechanism at low temperatures. Remarkably, temperature-triggered pendant isomerization can override this helix preference, leading to an "abnormal

SUBMITTER: Wang D 

PROVIDER: S-EPMC12728750 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature