Trimester and sex-specific associations of maternal thyroid profile with neonatal thyroid-stimulating hormone.

ABSTRACT:

Background

Maternal thyroid hormones have been shown to affect neonatal thyroid function. However, it remains unclear whether these associations persist across trimesters, and also little is known regarding the potential effects of mixtures.

Objective

This study aimed to examine the effects of maternal thyroid hormones as individual and as mixtures across three trimesters on neonatal thyroid stimulating hormone (TSH).

Methods

We included 2,139 pregnant women. Maternal thyroid hormones (TSH, free triiodothyronine (FT3), and free thyroxine (FT4)) across three trimesters and neonatal TSH level were measured. Multivariable linear regression models and Bayesian kernel machine regression (BKMR) models were used to examine the associations between maternal thyroid hormones (

SUBMITTER: Zhou B 

PROVIDER: S-EPMC12728804 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature