YAP1 inhibition protects retinal vascular endothelial cells under high glucose by inhibiting autophagy.

ABSTRACT: Diabetic retinopathy (DR) is a frequent diabetes-associated microvascular disorder, and its underlying mechanism of pathogenesis remains unclear. Previous studies have suggested that YAP1 is involved in endothelial activation and vascular inflammation. In the present study, we explored the biological role of YAP1 in retinal vascular endothelial cells (RVECs) in response to high glucose (HG). YAP1 expression was first evaluated in retinal endothelial cells cultured with HG. In retinal endothelial cells, the consequences of HG exposure and the alteration of YAP1 expression were systematically evaluated, focusing on cell growth, survival, tube formation, migration, and activation of autophagy. To further evaluate the protective effect of YAP1 inhibition on retinal endothelial cells in vivo

SUBMITTER: Li YS 

PROVIDER: S-EPMC12728944 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature