Multichiral Half-Sandwich Ru(II) and Os(II) Anticancer Complexes Containing a Glutathione Synthesis Inhibitor.

ABSTRACT: Two novel half-sandwich organometallic complexes, [(p-cymene)-M-(XY)-Cl], XY = L-BSO, M = Ru^II (Ru-LBSO), Os^II (Os-LBSO), containing the amino acid L-buthionine sulfoximine (L-BSO), as well as their XY = glycine analogs (Ru-Gly and Os-Gly), have been synthesized, characterized and their solution chemistry investigated. L-BSO is an inhibitor of the enzyme γ-glutamyl cysteine synthetase and, hence, glutathione synthesis. The diastereomers of Ru-LBSO and Os-LBSO were also characterized by DFT calculations which suggested the higher stability of [S_M,r_S] and [S_M,s_S] compared to [R_M,r_S] and [R_M,s_S] configuration

SUBMITTER: Kumari P 

PROVIDER: S-EPMC12728982 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature