Growth factor and cell content in Platelet-Rich Plasma (PRP), Leukocyte- and Platelet-Rich Plasma (L-PRP), Platelet-Rich Fibrin (PRF) in patients with long bone defects from combat injuries.

ABSTRACT:

Background

In contemporary regenerative medicine, platelet concentrates (PCs) are actively used as a promising method to support the regenerative process. However, the lack of standardized preparation protocols and the selection of PC types limits their broad clinical implementation, particularly in patients with non-unions or bone defects. Therefore, the aim of this study was to determine the concentration of platelets, leukocytes, and growth factors such as vascular endothelial growth factor (VEGF-A), transforming growth factor beta (TGF-β1), platelet-derived growth factor (PDGF-BB) in three types of PC, such as platelet-rich plasma (PRP), leukocyte- and platelet-rich plasma (L-PRP), platelet-rich fibrin (PRF) using a single donor model in patients with large bone defects after c

SUBMITTER: Husak V 

PROVIDER: S-EPMC12728992 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature