DNA-guided 3D pathway reconfiguration of composite nanopores for ion transport regulation.

ABSTRACT: Ion current rectification (ICR) is essential for understanding analyte-driven nanofluid transport within nanopores. However, the rapid flow rates and limited reaction times in this process can impede electrochemical reactions at electrode interfaces, which consequently lead to electrical noise challenges. Here, we propose a simple strategy to enhance the ICR effect and reduce noise interference through the construction of bio/solid composite pores. The composite pores comprise θ-shaped glass pores that have been sequentially modified with 3-glycidyloxypropyltrimethoxysilane (GLYMO), succinic anhydride (SA) and single-stranded DNA. Three-dimensional (3D) biochannels formed from acrylamide-DNA hydrogels are integrated within glass pores. High-density 3D channels and a highly viscous environm

SUBMITTER: Guo J 

PROVIDER: S-EPMC12728999 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature