Arterial collagen IV and laminin levels associate with type 2 diabetes, glycemic control, major adverse cardiac events, and mortality in coronary bypass patients.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) is associated with arterial diseases; particularly, the incidence of atherosclerotic conditions is increased among patients with diabetes. Basement membrane (BM) protein levels are increased in the artery wall of T2DM patients, but the underlying mechanisms and potential consequences remain elusive. This study aimed to identify putative connections between the level of arterial BM components, clinical characteristics, all-cause mortality and major adverse events (MACE) in groups of patients with and without T2DM.

Methods

Internal thoracic artery samples from 668 patients undergoing coronary artery bypass graft surgery at Odense University Hospital, Denmark, from 2008 to 2018 were included, of which 27% were diagnosed with T2DM. Seve

SUBMITTER: Faarvang AA 

PROVIDER: S-EPMC12729003 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature