Hemodynamic subphenotypes in septic shock and their different responses to fluid balance in relation to ICU mortality.

ABSTRACT:

Background

Hemodynamically unstable septic patients often require aggressive fluid resuscitation, but limited evidence exists on which hemodynamic subphenotypes benefit most.

Methods

The retrospective cohort study conducted in a tertiary hospital of China. Patients with septic shock who underwent pulse index continuous cardiac output (PiCCO) monitoring within 24 h were included from November 2013 to January 2024. We applied latent profile modelling to identify subphenotypes using all hemodynamic parameters monitored via PiCCO. We then tested the association of 48-h fluid balance with ICU mortality in different subphenotypes using logistic regression.

Result

A total of 691 patients were included. Latent profile models indicated that a four-profile model was the best fi

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12729010 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature