Enzyme-driven triplex structure-based DNA logic circuits.

ABSTRACT: DNA logic circuits have emerged as crucial media for biological computing due to their molecular-level parallelism and high biocompatibility. In the two mainstream systems currently prevalent, the strand-displacement system generally suffers from issues such as high strand complexity, signal leakage, and difficulties in cascading. In comparison, the enzyme-driven system has offered a further improvement in high rates and low leakage. However, it continues to encounter challenges pertaining to signal leakage and signal attenuation, which limit the development of intricate computational systems.This study introduces enzyme-powered triplex DNA logic circuits that simplify strand design through input-gate concatenation forming triplex structures, utilizing Bst 3.0 polymerase for efficient oper

SUBMITTER: Liu X 

PROVIDER: S-EPMC12729061 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature