PRSS55 regulates BCAA metabolism and interacts with BCKDK and BCKDHA in mouse testes and sperm.

ABSTRACT:

Backgrounds

Recent research has emphasized the significance of testis-specific serine proteases in regulating various aspects of sperm maturation and function. Among them, serine protease 55 (PRS55) plays an important role in the energy metabolism of sperm and is essential for male fertility in mice. A recent case study further suggests its potential importance to human fertility. However, the underlying molecular mechanism by which PRS55 influences sperm function are still not well understood. The present study aims to investigate these mechanisms further.

Results

In this study, we found impaired mitochondrial function in Prss55^-/- testes and sperm with low ATP production, and decreased mitochondrial membrane potential in sperm. We then validated that PRSS55 is m

SUBMITTER: Ge H 

PROVIDER: S-EPMC12729118 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature