Repeated cryopreservation is associated with poor pregnancy outcomes after frozen-thawed embryo transfer in women aged < 35 years: a propensity-score matched cohort study.

ABSTRACT:

Background

Repeated cryopreservation of embryos in frozen-thawed embryo transfer (FET) has raised concerns regarding its impact on pregnancy outcomes. This study aimed to reveal the association between repeated cryopreservation by vitrification and FET outcomes, and to identify factors influencing these outcomes.

Methods

A single-center retrospective cohort study was conducted, analyzing 13,624 FET cycles (from 2018 to 2022) involving embryos with cryopreservation or repeated cryopreservation. Propensity score matching was employed in this study. The primary outcome was clinical pregnancy rate (CPR) while live birth rate (LBR), miscarriage along with neonatal outcomes were also assessed. Multivariate logistic regression and stratified analyses were used to explore the effect

SUBMITTER: Huang Z 

PROVIDER: S-EPMC12729158 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature