Development of a Stereolithography 3D Printing-Based Micropatterning Method to Study Endothelial-to-Mesenchymal Transition Mechanobiology.

ABSTRACT: Endothelial-to-mesenchymal transition (EndMT) is the process of endothelial cells undergoing molecular changes that shift their phenotype from that of endothelial cells to that of mesenchymal-like cells. It is a crucial developmental process that has been implicated in various physiological and pathological conditions. EndMT has gained attention as a potential therapeutic target for cardiovascular disease processes, including atherosclerosis, myocardial fibrosis, and vascular calcification. In addition to the assessment of endothelial and mesenchymal markers, the behavioral mechanics of endothelial cells, such as migration and invasion, are often used to identify endothelial cells that have undergone EndMT. However, whether cell chirality may be another mechanobiological marker of EndMT re

SUBMITTER: Bender K 

PROVIDER: S-EPMC12729161 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature