Biomimetic dual-crosslinked GelMA-SilMA hydrogel microneedle for delivering DSPE-PEG2K-TAT-modified quercetin liposomes to treat rheumatoid arthritis via the caspase-8/caspase-3/GSDME pathway.

ABSTRACT: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovitis, whose pathogenesis remains unclear. Fibroblast-like synoviocytes (FLS) are central to the pathogenesis and progression of RA. This study aims to investigate the novel role of the pyroptosis mechanism mediated by the caspase-8/caspase-3/gasdermin-E (GSDME) pathway in RA-FLS, and further develop a transdermal drug delivery system (TDDS) to deliver quercetin (QUE) nanoparticles, which act on this pathway by targeting caspase-8. Specifically, we designed and constructed a 3D bioprinted bionic and architecture-mimetic double-crosslinked hydrogel dissolvable microneedle (MN) based on gelatin methacrylamide (GelMA) and silk fibroin methacryloyl (SilMA). This microneedle is used for transdermal delivery of quer

SUBMITTER: Zheng Q 

PROVIDER: S-EPMC12729175 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature