Regional and interregional brain functional abnormalities in major depressive disorder with childhood maltreatment.

ABSTRACT:

Background

Childhood maltreatment (CM) significantly enhances the vulnerability to major depressive disorder (MDD), but the relationship with brain dysfunction remains uncertain.

Methods

We recruited 84 MDD patients (52 with CM, 32 without CM) and 54 healthy controls. Regional brain activity was assessed using amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), degree centrality, and regional homogeneity. The identified abnormal regions were used as seeds for functional connectivity (FC) analysis. We employed partial correlation and moderated mediation to explore the relationships between CM, brain dysfunction, MDD severity, and dysfunctional attitudes.

Results

MDD patients with CM had reduced ALFF in the right posterior orbitofrontal cortex (pOFC)

SUBMITTER: Luo Q 

PROVIDER: S-EPMC12729193 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature