Tannic acid inhibits diquat induced human renal HK-2 cells apoptosis through BAX/Bcl2/caspase/cleaved caspase-3 signaling pathway.

ABSTRACT:

Background

Diquat (DQ) exposure can cause acute kidney failure and rhabdomyolysis. Accordingly, the current study aimed to assess how DQ toxicity affects the viability of human proximal tubular cells (HK-2) and to evaluate the potential protective effects of Tannic acid (TA) in this experimental model.

Methods

HK-2 cells were divided into groups: negative control, positive control, DQ alone, and DQ combined with TA at concentrations of 0.5, 2.5, and 5 μmol/L for 24 h. Subsequently, cell viability, reactive oxygen species (ROS) production, oxidative stress and inflammatory marker concentrations, as well as the expression of apoptosis-related genes, were evaluated in all groups.

Results

The data indicate that DQ significantly increased ROS production and elevated the le

SUBMITTER: Radan M 

PROVIDER: S-EPMC12729203 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature