The association between sedentary behavior and infertility: a population-based cross-sectional observational study and Mendelian randomization analysis.

ABSTRACT:

Objective

The relationship between sedentary behavior and infertility remains ambiguous and contentious. This study seeks to elucidate this association by analyzing data from the 2013-2018 National Health and Nutrition Examination Survey (NHANES), coupled with Mendelian randomization (MR) analyses.

Methods

Our analysis comprised 2904 female participants, aged 20 to 49 years, enrolled in the National Health and Nutrition Examination Survey (NHANES) during the 2013-2018 cycles. Weighted multivariate logistic regression model was employed to examine the association between sedentary behavior and infertility, with sensitivity analysis conducted to validate the robustness of the findings. In addition, we used restricted cubic spline (RCS) curves to explore any non-linear associat

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12729209 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature