Intranasally administered muse cells attenuate neurodegeneration in Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease is a neurodegenerative disorder primarily caused by the degeneration and death of dopaminergic neurons in the substantia nigra. Multilineage differentiating stress enduring (Muse) cells are a novel type of stem cells discovered in recent years, exhibiting superior tissue regenerative capabilities compared to regular mesenchymal stem cells, including multi-lineage differentiation potential, stress tolerance, homing ability, in situ differentiation capacity, and non-tumorigenic properties. Here we investigated the effect and mechanism of muse cell in crossing blood-brain barrier (BBB), and improving Parkinson's disease-related phenotypes.

Methods

We used transwell to construct an in vitro blood-brain barrier model and treated it with muse cells a

SUBMITTER: Lu Z 

PROVIDER: S-EPMC12729229 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature